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摘要:
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目的:探讨套细胞淋巴瘤的临床病理与免疫组化特点及鉴别诊断.方法:收集5例套细胞淋巴瘤做临床病理观察,免疫组化二步法做免疫表型分析.结果:5例套细胞淋巴瘤中男女之比为 4∶1,年龄37~74岁,平均58.4岁.光镜下可将套细胞淋巴瘤分为:套区型1例,结节型3例,弥漫型 1例,肿瘤细胞表达全B细胞标记.结论:套细胞淋巴瘤是一种具有特殊免疫表型的B 细胞淋巴瘤,不同的组织学构型其预后可能不同,临床应与其它类型B 细胞淋巴瘤鉴别.
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参考文献:
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Schroers R.Hildebrandt Y.Steffens R Immunophenotypic and genetic characterization of a CD8 positive mantle cell lymphoma in a patient with concomitant Mycosis fungoides 2005(1) Decaudin D Mantle cell lymphoma:a biological and therapeutic paradigm 2002(4) Campo E.Raffeld M.Jaffe E S Mantle-cell lymphoma 1999(2) Bertoni F.Zucca E.Cotter F E Molecular basis of mantle cell lymphoma 2004(2) 何小金.李甘地.刘卫平.林友胜.李俸媛.廖殿英 套细胞淋巴瘤的临床病理特征和细胞周期蛋白D1在诊断中的意义 2002(4) Yatabe Y.Suzuki R.Tobinai K Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma:a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma 2000(7) Camacho F I.Garcia J F.Cigudosa J C Aberrant Bcl6 protein expression in mantle cell lymphoma 2004(8) Ek S.Bjorck E.Porwit-Macdonald A Increased expression of Ki-67 in mantle cell lymphoma is associated with de-regulation of several cell cycle regulatory components,as identified by global gene expression analysis 2004(6) 李甘地.刘卫平 从争论到统一--介绍WHO新的恶性淋巴瘤分类 2001(2)
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