|
电话：010-52995241/57181307
地址：北京市朝阳区西坝河中里35号12信箱，邮编：100028
|
|
摘要：
|
|
胰腺干细胞分子标志对基础和临床研究均有重要意义.通过识别胰腺干细胞表面特异的分子标志,可以从众多其他细胞中鉴定、分离及纯化出胰腺干细胞.对胰腺干细胞分子标志物的掌握是胰腺干细胞治疗研究的基础和重点,但目前缺乏唯一的干细胞标志物和可信的评价指标.此文将介绍目前已知的胰腺干细胞分子标志物及其现状.
|
|
|
|
基金项目：
|
|
广西自然科学基金
|
|
作者简介：
|
|
|
|
参考文献：
|
|
Santana A.Enseat-Waser R.Arribas MI Insulinproducing cells derived from stem cells:recent progress and future directions 2006(4) Bonner-weir S.Taneja M lnvitro cultivation of human islets from expanded ductal tissue 2000(14) 朱岚 PDX-1基因的表达与调节 2005(1) Docherty K Growth and developmengt of the islets of Langerhans implications for the treatment of diabetes mellitus 2001(6) Dutta S.Bonner-Weir S.Montminy M Regulatory factor linked to late-onset diabetes 1998(6676) Taguchi M.Yamagnchi T.Otsuki M Induction of PDX-1-positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats 2002(5) Petri A.Ahnfelt-Ronne J The effect of neurogenin3 deftcieney on pancreatic gene expression in embryonic mice 2006(2) 宋陆军.秦新裕.牛伟新.沈坤堂.刘凤林.K.A.Andreoni.D.A.Gerber.J.H.Fair.L.Rice.A.Pleasant.J.Wang 源于体外培养胰岛中表达Ngn3的细胞是胰腺内分泌前体细胞的新证据 [期刊论文] -中华外科杂志2005(1) Sugiyama T.Redriguez RT Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS 2007(1) Apelqvist A.Li H Notch signalling controls pancreatic cell differentiation 1999(6747) Zhao M.Amiel SA Amelioration of streptozotocin-induced diabetes in mice with cells derived from human marrow stromal cells 2008(7) Zhao M.Amiel SA.Christie MR Evidence for the presence of stem cell-like progenitor cells in human adult pancreas 2007(3) Wang H.Wang S.Hu J Oct4 is expressed in Nestin-positive cells as a marker for pancreatic endocrine progenitor 2009(5) Lang D.Powell SK PAX genes:roles in development,pathophysiology,and cancer 2007(1) Greenwood AL.Li S Notch signaling reveals developmental plasticity of Pax4 (+)pancreatic endocrine progenitors and shunts them to a duct fate 2007(2) Wang J.Elghazi L The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation Zulewski H.Abraham EJ Multipetential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine,execrine,and hepatic phenotypes 2001(3) Yashpal N Characterization of c-Kit and Nestin expression during islet cell development in the prenatal and postnatal rat pancreas 2004 Zhang L.Hong TP.Hu J Nestin-positive progenitor cells isolated from human fetal pancreas have phenotypic markers identical to mesenchymal stem cells 2005(19) Lammert E.Brown J.Melton DA Notch gene expression during pancreatic organogenesis 2000(1-2) Apelqvist A.Li H.Sommer L Notch signalling controls pancreatic cell differentiation 1999(6747) Yokoyama-Hayashi K.Takahashi T.Kakita A Expression of PGP 9.5 in ductal cells of the rat pancreas during development and regeneration:can it be a marker for pancreatic progenitor cells 2002(1) Edling CE.Hallberg B "c-Kit--a hematopoietic cell essential receptor tyrosine kinase".Int.J.Biochem 2007(11) J(a)szai J.Fargeas CA.Florek M Focus on molecules:prominin-1 (CD133) 2007(5) Mizrak D.Brittan M.Alison MR CD133:molecule of the moment 2008(1) Shmelkov SV CD133 expression is not restricted to stem cells,and both CD133 + and CD133-metastatic colon cancer cells initiate tumors 2008(6) Rodolosse A.Campos ML p/CAF modulates the activity of the transcription factor p48/Ptfl a involved in pancreatic acinar differentiation 2009(2) Fujitani Y.Fuhitani S Ptfla determines horizontal and amacrine cell fates during mouse retinal development 2006(22) Sellick GS Mutations in PTFIA cause pancreatic and cerebellar agenesis 2004 Hoshino M Ptfla,a bHLH transcriptional gene,defines GABAergic neuronal fates in cerebellum 2005(2) Schmied BM.Ulrich A Transdifferentiation of human islet cells in a long-term culture 2001(2) Di Bella A.Regoli M An appraisal of intermediate filament expression in adult and developing pancreas:vimentin is expressed in alpha cells of rat and mouse embryos 2009(6) Glasgow SM Ptfla determines GABAergic over gluta matergic neuronal cell fate in the spinal cord dorsal horn 2005(24) Budison JS.Long Q Pdx-1 and Ptfl a concurrently determine fate specification of pancreatic multipotent progenitor cells 2008(1) Pavlakis M.Khwaja K Transplantation for type 1 diabetes:whole organ pancreas and islet cells 2006(6) Kobayashi N Cell therapy for diabetes mellitus 2006(10)
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|
